Blogs
From Vitamin Discovery to Vascular Medicine: The Guardians of Blood Vessels Revealed by the Mystery of Scurvy
Tracing the history of how the unraveling of 'mysterious diseases' like scurvy, beriberi, and rickets led to the discovery of vitamins and revealed their deep connection to vascular health.
February 6, 2026
The Antioxidant Paradox: Why 'Supplement Overload' Can Backfire
Filling a deficiency and piling on excess are two completely different things. Explaining the 'Antioxidant Paradox' where well-intentioned supplementation can shorten lifespan, based on evidence from CARET and SELECT trials.
February 4, 2026
Vitamins and Vascular Health: Beyond C and E
Explaining the role of vitamins other than C and E (B complex, D, K, A) in vascular health, focusing on homocysteine metabolism, potential calcification prevention, and RAAS inhibition.
February 3, 2026
Effects of Vitamin E on Vascular Endothelial Function: The Mysterious Relationship Between Single Intake and Combination
Explaining the effects of Vitamin E (tocopherol) intake on vascular endothelial function from meta-analyses and specific pathologies (dialysis, diabetes). Also mentioning the combined effect with Vitamin C.
January 28, 2026
How Much Vitamin C is "Appropriate"? Safe Dosage Based on Evidence and Risk of Overdose
Is it true that 'Vitamin C is water-soluble, so it's okay to take as much as you want'? We derive the optimal intake based on pharmacokinetics data and the latest evidence on risks such as kidney stones and gastrointestinal symptoms.
January 27, 2026
Why Does Vitamin C Improve Vascular Endothelial Function? Deep Dive into Molecular Mechanisms
The deep relationship between Vitamin C and vascular endothelium cannot be explained solely by 'being an antioxidant vitamin'. Explaining the mechanism focusing on eNOS uncoupling and BH4 stabilization.
January 23, 2026
Does Vitamin C Improve Endothelial Function? Reading Short-term and Long-term Evidence from an FMD Perspective
Summarizing key points on the effects of short-term (single dose to hours) and long-term (weeks+) Vitamin C (ascorbic acid) intake on vascular endothelial function from representative trials and meta-analyses.
January 4, 2026